Its’s hard to think of one disease that is not affected by physical activity. Take the two major killers: heart disease and cancer. The heart requires exercise to grow properly. Exercise increases the peripheral arteries and decreases your cholesterol levels; it decreases your risk of heart disease by at least half.
Breast cancers and many other reproductive tissue cancers also respond strongly to exercise. Other factors being constant, women who have engaged in regular vigorous exercise have significantly lower cancer rates than women who have not. Colon cancer has been shown to be reduced by up to 30 percent by exercise. There are also benefits for mental health—depression, anxiety, the list is incredibly long